Department of Pharmacology

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Cardiovascular Physiology and Pharmacology During Hypoxia and Reoxygenation in Newborns. My research consists of both clinical as well as basic science studies in the neonate. I investigate the effects of novel interventions in critically ill neonates and the long-term outcome in early childhood. Newborn piglet is the animal model used in the laboratory for basic science studies. The current focus of the Neonatal Sciences Laboratory is on the effects of hypoxia-reoxygenation injury and the actions of inotrope and other cardiovascular supportive drugs in systemic and regional circulations and platelet functions.

Liu JQ, Lee TF, Bigam DL, Cheung PY. (2010) Effects of post-resuscitation treatment with N-acetylcysteine on cardiac recovery in hypoxic newborn piglets. PLoS One. 5, e15322. PMID: 21203535.

Liu JQ, Lee TF, Chen C, Bigam DL, Cheung PY. (2010) N-acetylcysteine improves hemodynamics and reduces oxidative stress in the brains of newborn piglets with hypoxia-reoxygenation injury. J Neurotrauma. 27, 1865-1873. PMID: 20649480.

Emara M, Obaid L, Johnson S, Bigam DL, Cheung PY. (2010) Angiostatins decrease in the kidney of newborn piglets after hypoxia-reoxygenation. Eur J Pharmacol. 644(1-3), 203-208. PMID: 2062108.

Joynt C, Bigam DL, Charrois G, Jewell LD, Korbutt G, Cheung PY. (2010) Milrinone, dobutamine or epinephrine use in asphyxiated newborn pigs resuscitated with 100% oxygen. Intensive Care Med. 36, 1058-1066. PMID: 20221750.

Chapados I, Chik CL, Cheung PY. (2010) Plasma cortisol response to ACTH challenge in hypoxic newborn piglets resuscitated with 21% and 100% oxygen. Shock. 33, 519-525. PMID: 19924031.

Viappiani, S., Nicolescu, A.C., Holt, A., Sawicki, G., Crawford, B.D., Leon, H., Van Mulligen, T. & Schulz, R. (2008) Activation and modulation of 72 kDa matrix metalloproteinase-2 by peroxynitrite and glutathione. Biochem. Pharmacol., 77(5), 826-834. PMID 19046943.

Webster, N.J., Searle, G.J., Lam, P.P.L., Huang, Y.-C., Riedel, M.J., Harb G., Gaisano, H.Y., Holt, A. & Light, P.E. (2008) Elevation in intracellular long chain acyl-coenzyme A esters lead to reduced β-cell excitability via activation of adenosine 5'-triphosphate-sensitive potassium channels. Endocrinology, 149(7), 3679-3687. PMID 18372336.