B. Kerr

Dr Bradley J Kerr

(Adjunct Associate Professor)

Contact:

Office: 9-28A Medical Sciences Bldg.  (☎) 780.492.3380
Lab: 9-28 Medical Sciences Bldg.  (☎) 780.492.3268
bradley.kerr@ualberta.ca

Education:
BPhD-Neuroscience, University of London-King's College, London UK 2001
BSc-Psychology, McGill University, 1996

Teaching: PMCOL412

Research: Mechanisms of chronic pain after CNS injury or disease


Research Interests / Laboratory Techniques

The development of chronic pain after spinal cord injury or in diseases such as multiple sclerosis (MS) is a major clinical concern. The main focus of research in my laboratory is aimed at addressing the cellular mechanisms that generate neuropathic pain in these conditions. My research uses two primary animal models: a clinically relevant spinal contusion injury model and a mouse model of autoimmune demyelination that resembles MS, experimental autoimmune encephalomyelitis (EAE). My research aims to understand the specific pathways and cellular changes that arise in response to direct trauma or in chronic disease states that may promote the development of neuropathic pain. The lab employs a number of different strategies that include analysis at the cell and molecular levels, as well as systems level approaches to address this complex biological problem.


Selected Recent Publications

Mifflin KA and Kerr BJ. (2016) Pain in autoimmune disorders. J Neurosci Res [Epub ahead of print]. PMID: 27448322.

Potter LE, Paylor JW, Suh JS, Tenorio G, Caliaperumal J, Colbourne F, Baker G, Winship I and Kerr BJ. (2016) Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis. J Neuroinflammation 13(1):142. PMID: 27282914.

Yousuf MS and Kerr BJ. (2016) The Role of Regulatory Transporters in Neuropathic Pain. Adv Pharmacol 75:245-71. PMID: 26920015.

Mifflin KA, Benson C, Thorburn KC, Baker GB and Kerr BJ. (2015) Manipulation of Neurotransmitter Levels Has Differential Effects on Formalin-Evoked Nociceptive Behavior in Male and Female Mice. J Pain pii: S1526-5900(15)01001-9. PMID: 26748043.

Thorburn KC, Paylor JW, Webber CA, Winship IR and Kerr BJ. (2016) Facial hypersensitivity and trigeminal pathology in mice with experimental autoimmune encephalomyelitis. Pain 157(3):627-42. PMID: 26545087.

Benson C, Paylor JW, Tenorio G, Winship I, Baker G and Kerr BJ. (2015) Voluntary wheel running delays disease onset and reduces pain hypersensitivity in early experimental autoimmune encephalomyelitis (EAE). Exp Neurol 271:279-290. PMID: 26033473.

Gutierrez NA, Serao NV, Kerr BJ, Zijlstra RT and Patience JF. (2014) Relationships among dietary fiber components and the digestibility of energy, dietary fiber, and amino acids, and energy content of 9 corn co-products fed to growing pigs. J Anim Sci 92(10):4505-17. PMID: 25149339.

Benson C and Kerr BJ. (2014) Pain and Cognition in Multiple Sclerosis. Curr Top Behav Neurosci 20:201-15. PMID: 24850077.

Mifflin KA and Kerr BJ. (2014) The transition from acute to chronic pain: Understanding how different biological systems interact. Can J Anaesth. 61(2):112-22. PMID: 24277113.

Benson CA, Wong G, Tenorio G, Baker GB, Kerr BJ. (2013) The MAO inhibitor phenelzine can improve functional outcomes in mice with established clinical signs in experimental autoimmune encephalomyelitis (EAE). Behav Brain Res. 252:302-311. PMID: 23777648.

Lieu A, Tenorio G, Kerr BJ. (2013) Protein Kinase C gamma (PKCγ) as a novel marker to assess the functional status of the corticospinal tract experimental autoimmune encephalomyelitis (EAE). J Neuroimmunol. 256(1-2):43-48. PMID: 23385082.

Olechowski, CJ, Tenorio G, Sauve Y, Kerr BJ. (2013) Changes in nociceptive sensitivity and object recognition in experimental autoimmune encephalomyelitis (EAE). Exp Neurol. 241:113-121. PMID: 23291347.

Mifflin KA, Kerr BJ (2013) Sex-related differences in acute and chronic pain: a bench to bedside perspective. Can J Anaesth 60(3):221-226. PMID: 23288582.

Musgrave T, Benson C, Wong G, Browne I, Tenorio G, Rauw G, Baker GB and Kerr BJ (2011) The MAO inhibitor phenelzine improves functional outcomes in mice with experimental autoimmune encephalomyelitis (EAE). Brain Behav Immun 25:1677-1688. PMID: 21723939.

Musgrave T, Tenorio G, Rauw G, Baker GB and Kerr BJ (2011) Tissue concentration changes of amino acids and biogenic amines in the central nervous system of mice with experimental autoimmune encephalomyelitis (EAE). Neurochem Int 59:28-38. PMID: 21672584.

Olechowski CJ, Parmar A, Miller B, Stephan J, Tenorio G, Tran K, Leighton J, and Kerr BJ. (2010). A diminished response to formalin stimulation reveals a role for the glutamate transporters in the altered pain sensitivity of mice with experimental autoimmune encephalomyelitis (EAE). Pain 149 (3): 565-572. PMID: 20399559.

Olechowski CJ, Truong J. and Kerr BJ. (2009). Neuropathic pain behaviours in a chronic-relapsing model of experimental autoimmune encephalomyelitis. Pain 141 (1-2): 156-164. PMID: 19084337.